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अत्यधिक विषाक्त — गुर्दे की विफलता

मेरे कुत्ते ने एंटीफ्रीज पिया: अब क्या करें

emergency.ateAntifreeze.banner.subtitle

अभी क्या करें

  1. 1

    EMERGENCY VET NOW

    Go to the nearest emergency vet immediately. Call ASPCA Poison Control at (888) 426-4435 en route. Every minute counts.

  2. 2

    Do NOT Wait for Symptoms

    By the time symptoms appear, kidney damage may be irreversible. The antidote must be given within 8-12 hours to be effective.

  3. 3

    Bring the Container

    Take the antifreeze container to the vet. This confirms the active ingredient (ethylene glycol) and concentration.

  4. 4

    Treatment Window is Critical

    Your vet will administer fomepizole (4-MP) or ethanol IV to block metabolism. After 12 hours, treatment is much less effective.

इसके पीछे का विज्ञान

इथाइलीन ग्लाइकॉल खुद विषैला नहीं है — यह लिवर द्वारा उत्पन्न मेटाबोलाइट्स हैं जो क्षति पैदा करते हैं। अल्कोहल डिहाइड्रोजनेज इथाइलीन ग्लाइकॉल को ग्लाइकोलेट में बदलता है, फिर ऑक्सालेट में। कैल्शियम ऑक्सालेट गुर्दों में क्रिस्टलीभूत होता है, जिससे तीव्र गुर्दे की विफलता होती है।

अक्सर पूछे जाने वाले प्रश्न

How much antifreeze is lethal to dogs?

As little as 1 teaspoon (5ml) of antifreeze can kill a 10lb (4.5kg) dog. The lethal dose of ethylene glycol is approximately 4.4ml per kg of body weight. This makes antifreeze one of the most dangerous household toxins for pets.

How fast does antifreeze kill dogs?

Without treatment, antifreeze is fatal within 12-36 hours. The antidote (fomepizole or ethanol) must be administered within 8-12 hours of ingestion to be effective. After kidney failure begins, survival rates drop dramatically.

What are the symptoms of antifreeze poisoning?

Stage 1 (30 min-12 hrs): drunken behavior, vomiting, seizures. Stage 2 (12-24 hrs): apparent improvement (misleading). Stage 3 (24-72 hrs): kidney failure, severe lethargy, mouth ulcers, coma. Early treatment is critical.